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A Pilot Open-Label Study Assessing the Effects of AHCC Supplementation on Lyme Disease Patients
John Salerno, Manami Misu, Eriko Ogawa, Jun TakanariABSTRACT Background: Lyme disease is the most commonly reported vector-borne illness in the United States. The disease is caused by the bacterium Borrelia burgdorferi and is transmitted to humans through the bite of infected ticks. Typical symptoms include fever, headache, fatigue, a skin rash, and joint pain. If left untreated, infection can spread to the joints, heart, and nervous system, resulting in inflammation and long-term symptoms that include arthritis and/or intermittent pain in joints and muscles, facial palsy, cardiovascular abnormalities and cognitive disturbances.
Recent research suggests that late-stage Lyme disease may be a result of malfunctioning immune function. AHCC is a natural immune modulating compound derived from a unique fraction of special cultured medicinal mushroom mycelia. Previous studies have also suggested that AHCC exhibits preventive effect against a wide range of infections caused by MRSA, influenza and West Nile virus. The effect of AHCC supplementation on Lyme disease patients was evaluated in the current study.
Methods: In a pilot open-label study, 12 Lyme disease patients were administered 3 grams of AHCC daily for 8 weeks. Before commencement of the administration and after 4 and 8 weeks, the effects of AHCC were evaluated clinically based on symptoms, serum antibodies to pathogens, inflammatory activity and serum immunological parameters. Patients completed questionnaires pertaining to Qualify of Life parameters.
Results: After 8 weeks of AHCC administration, AHCC ameliorated flu-like symptoms and manifestations in the eye, joint, muscle, nervous system and cardiovascular system. In addition, Bioactive Compounds in Health and Disease 2019; 2(11): 221-229 Page 222 of 229
erythrocyte sedimentation rate, an index as inflammation and serum interleukin-8 was significantly decreased.
CONCLUSION. This pilot study provides preliminary evidence that AHCC® may be effective in reducing symptoms and improving immune function in LD patients. While LD is a complex and its etiology is not completely understood, the immunomodulatory activity of AHCC® appears to enhance the body’s own response to the bacteria infection, as well as help counteract immune dysfunction that results in inflammation and symptoms associated with PTLDS. Additional studies are now needed to determine the mechanism of action of AHCC® as an immunomodulatory agent in LD. To clarify the effects of AHCC® on LD, placebo-controlled clinical studies in more subjects and further studies to elucidate the mechanism of action of AHCC® as an immunomodulator are needed.
The Salerno Center for Complementary Medicine, New York, NY, 10022, USA; 2Amino Up Co., Ltd., Sapporo, Hokkaido, 004-0839, Japan
Corresponding author: Manami Misu, PhD, Amino Up Co., Ltd., Sapporo, Hokkaido, 004-0839, Japan Submission Date: November 15th, 2019. Acceptance Date: November 30th , 2019. Publication Date: November 30th, 2019 Citation: Salerno J., Misu M., Eriko Ogawa E., Jun Takanari2. A Pilot Open-Label Study Assessing the Effects of AHCCÒ Supplementation on Lyme Disease Patients. Bioactive Compounds in Health and Disease 2019; 2(11): 221-229. DOI: 10.31989/bchd.v2i11.677
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How is AHCC Researched and Tested?
AHCC has undergone extensive research and testing in pre-clinical, in vitro, and human clinical studies.
AHCC is a functional food that is derived from healing mushrooms. AHCC is clinically tested and proven to support improved immune system health. AHCC has been studied extensively for over 20 years.
For healthy people, AHCC is useful in health maintenance and in preventing infection by aiding in the normal function of your immune system.
In integrative oncology, research indicates that AHCC may lead to longer post-operative survival, help support patients through chemotherapy, reduce the negative effects of chemotherapy and radiation, and lead to an improvement in quality of life.
AHCC is a focus of research at prestigious institutions through-out the world. AHCC has been the subject of over 100 published papers, including 30 human clinical studies.
PRE-CLINICAL AND IN VITRO STUDIES ABOUT AHCC
The Pre-Clinical and In Vitro Studies page is your direct resource and access point for all pre-clinical and in vitro studies done about AHCC.
The following pre-clinical and in vitro studies about AHCC have been completed:
- Pre-Clinical and In Vitro Studies – Cancer
AHCC has been used with great success in cancer patients. Data from the treatment of over 100,000 individuals with various types of cancer have shown AHCC treatment to be of benefit in 60% of cases.
- Pre-Clinical and In Vitro Studies – Chemo Side Effects
For many cancer patients, the impacts of chemotherapy can be very challenging and impact patient ability to recover from cancer. Learn more about how AHCC has been studied and researched with respect to its impacts on chemotherapy side effects.
- Pre-Clinical and In Vitro Studies – Liver
Learn more about how AHCC has been studied and researched with respect to its impacts on liver disease, including hepatitis.
- Pre-Clinical and In Vitro Studies – Infection
Infection can be devastating for the immune system and overall health and wellness. As a result, we’ve heavily studied the impacts AHCC has on the ability to recover from and defend against infection.
- Pre-Clinical and In Vitro Studies – Other
Learn more about AHCC studies and research related to a range of conditions and diseases. For example, learn how AHCC has been researched as an anti-inflammatory, how it may prevent and treat Diabetes, and about the recent progress of research on AHCC.
HUMAN CLINICAL STUDIES ABOUT AHCC
The Human Clinical Studies page gives you direct access to the clinical studies completed about AHCC and its effectiveness.
The following human clinical studies about AHCC have been completed:
- Human Clinical Studies – Cancer
AHCC has been used with great success in cancer patients. Data from the treatment of over 100,000 individuals with various types of cancer have shown AHCC treatment to be of benefit in 60% of cases.Learn more about how AHCC has been studied and researched with respect to its impacts on cancer treatment, recovery from specific cancer types, and immune system response.
- Human Clinical Studies – Chemo Side Effects
For many cancer patients, the impacts of chemotherapy can be very challenging and impact patient ability to recover from cancer. Learn more about how AHCC has been studied and researched with respect to its impacts on patient ability to manage and mitigate chemotherapy side effects.
- Human Clinical Studies – Liver
Learn more about how AHCC has been studied and researched with respect to its impacts on liver disease, including hepatitis, and alcohol-induced liver enzyme elevation.
- Human Clinical Studies – Healthy Adults
AHCC is not just for people dealing with illness or disease. Learn more about how AHCC has been researched with respect to its impacts on healthy individuals, including immune response to influenza vaccines and on people aged 50 years or older.
- Human Clinical Studies – Safety
The safety of any dietary supplement should be top-of-mind. Learn more about how AHCC has been studied and researched with respect to its safety for all types of individuals, including HPV-positive women, healthy individuals, and pharmacoresistant epilepsy patients.
YOU AND AHCC
We want you to know what we know about AHCC. This is why we urge you to download the research papers, to watch videos about AHCC, and to read our blog where we post articles about AHCC and your immune system health.
Contact us on your Lyme or Lyme-like disease through this form:
Medinstitute/Nikolenko Clinic working hours: Monday, Tuesday, Wednesday and Friday 8:30 – 13:00 / 15:30 – 20:00 Thursday and Saturday 8:30 – 13:00 Sunday Closed13-15, DIGENI AKRITA, NICOSIA, 1055, CYPRUS